...you should. It's an excellent addition to the Myst series. I've been playing Myst games since the first one came out and back then it was huge because of how revolutionary it was for a puzzle game.
I still have the same kind of passion for the series because no one else has done what the Myst games have done. Initially I was somewhat hesitant about Uru because I had skipped on the third one (Exile which I didn't even really hear about until long after it'd been released). But I went ahead, tried Uru, and have been best pleased with it.
The spec requirements are pretty high but I'm assuming that won't be a problem for most of the people here. Uru has a new dynamic from the other games I was familiar with because you have a character you design and play in 3rd person isometric. The controls are a bit clunky but that's fine cause you don't have to do complicated things really. The hardest part is navigating the very first intro level cause it's in somewhat close quarters and you aren't used to the movements yet.
Beyond that, though, the storyline is of the usual Cyan-quality, puzzles are challenging but rewarding, and the world environments... they're astounding. The movement and detail they achieve is a huge evolutionary step from the previous Myst games. It's gorgeous, to put it concisely, and anyone who likes beautiful games needs to check the game out.
